That depends on what you mean by "isolated".
If you want several TChromium instances to open the same website and log in with different accounts, then you need to pass a new ICefRequestContext to the CreateBrowserHost inside the TChromium.CreateBrowser function.
I've never done that but Marshall Greenblatt says that it can be done :
http://magpcss.org/ceforum/viewtopic.ph ... 34&p=26095